New Preclinical Data Highlighting Eleven Biotherapeutics’ DeBouganin Program to be Presented at 2018 AACR Annual Meeting
“We have uniquely designed our deBouganin payload to address tumor
indications that can only be reached through systemic delivery. Our data
show that deBouganin exhibits certain advantages over first-generation
ADCs, which use more conventional small molecule cytotoxins, with
respect to cell killing power, including the ability to kill cancer stem
cells, circumvent multi-drug resistance and avoid cross-resistance
DeBouganin is a proprietary de-immunized variant of bouganin, a ribosome
inactivating protein that when internalized blocks protein synthesis,
thereby leading to cell death.
Poster Title: VB6-845d Tumor Cell Killing Elicits Biologic
Features of Immunogenic Cell Death
Date and Time:
In addition, in collaboration with Crescendo Biologics, the company will present data demonstrating that a fusion protein comprised of the company’s deBouganin payload and Crescendo’s Humabody® are expressible as a soluble protein in E. coli supernatant. Crescendo’s Humabody products are a novel class of small, robust and potent protein therapeutics based on fully human VH domain building blocks. In vitro data support the potential of Humabody-deBouganin fusion constructs as anti-cancer therapeutics.
Poster Title: Engineering and Characterization of Anti-PSMA Humabody-DeBouganin Fusion Proteins
Date and Time:
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